7LLK
Cryo-EM structure of Q23.17_DS-SOSIP in complex with Glycan276-Dependent Broadly Neutralizing Antibody 179NC75 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I (E, A, I) | Envelope glycoprotein gp120 | polymer | 474 | 53627.9 | 3 | UniProt (O55774) | Human immunodeficiency virus 1 | |
| 2 | B, F, J (F, B, J) | Envelope glycoprotein gp41 | polymer | 153 | 17211.6 | 3 | UniProt (by SIFTS) (O55774) | Human immunodeficiency virus 1 | |
| 3 | C, G, K (G, C, K) | 179NC75 Fab Heavy chain | polymer | 238 | 25897.5 | 3 | Homo sapiens (Human) | ||
| 4 | D, H, L (H, D, L) | 179NC75 Fab Light chain | polymer | 215 | 23042.4 | 3 | Homo sapiens (Human) | ||
| 5 | FA, M, PA, V (f, M, q, V) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 6 | AA, BA, DA, EA, GA... (a, b, d, e, g...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 22 | In PDB GlyTouCan (G15407YE) | |||
| 7 | CA, HA, MA, RA, S... (c, h, n, s, S...) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 6 | In PDB GlyTouCan (G22573RC) | |||
| 8 | AB, BB, SA, TA, UA... (I, E, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) |
Sequence modifications
E, A, I: 32 - 508 (UniProt: O55774)
| PDB | External Database | Details |
|---|---|---|
| Ala 31 | - | expression tag |
| Cys 201 | Ile 193 | conflict |
| Ala 219 | Thr 211 | conflict |
| Ser 334 | Thr 325 | conflict |
| Cys 433 | Ala 423 | conflict |
| Lys 490 | Glu 480 | conflict |
| Cys 501 | Ala 491 | conflict |
| Arg 509 | - | expression tag |
| Arg 510 | - | expression tag |
| Arg 511 | - | expression tag |
| Arg 512 | - | expression tag |
| Arg 513 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 359338.1 | |
| Branched | Number of molecules | 32 |
| Total formula weight | 19093.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2212.1 | |
| All* | Total formula weight | 380643.8 |
