7LLH
KPC-2 F72Y mutant with acylated imipenem
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Carbapenem-hydrolyzing beta-lactamase KPC | polymer | 260 | 27623.1 | 2 | UniProt (Q9F663) Pfam (PF00144) Pfam (PF13354) | Klebsiella pneumoniae | Carbapenem-hydrolyzing beta-lactamase KPC-1 |
| 2 | C, D (A, B) | (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid | non-polymer | 301.4 | 2 | Chemie (IM2) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 290 (UniProt: Q9F663)
| PDB | External Database | Details |
|---|---|---|
| Tyr 72 | Phe 71 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55246.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 602.7 | |
| All* | Total formula weight | 55848.9 |
