7LL4
High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-114.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK2 | polymer | 297 | 34944.9 | 1 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | B (A) | {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile | non-polymer | 577.7 | 1 | Chemie (Y5D) | |||
| 3 | C (A) | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A: 839 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Ala 836 | - | expression tag |
| Phe 837 | - | expression tag |
| Ala 838 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34944.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 577.7 | |
| All* | Total formula weight | 35522.6 |
