7LHB

Crystal structure of Bcl-2 in complex with prodrug ABBV-167

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Apoptosis regulator Bcl-2	polymer	166	19355.6	3	UniProt (P10415) Pfam (PF02180) Pfam (PF00452)	Homo sapiens (Human)
2	D, E, F (A, B, C)	Phosphoric acid mono-[5-(5-{4-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-piperazin-1-yl}-2-{3-nitro-4-[(tetrahydro-pyran-4-ylmethyl)-amino]-benzenesulfonylaminocarbonyl}-phenoxy)-pyrrolo[2,3-b]pyridin-7-ylmethyl] ester	non-polymer		978.4	3	Chemie (XZD)
3	G, H, I (A, B, C)	water	water		18.0	205	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 75 (UniProt: P10415)

PDB	External Database	Details
Pro 4	Ala 4	engineered mutation
Lys 26	Arg 26	engineered mutation

A, B, C: 76 - 91 (PDB: 7LHB)
A, B, C: 92 - 207 (UniProt: P10415)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	58066.7
Non-Polymers*	Number of molecules	3
	Total formula weight	2935.3
All*	Total formula weight	61002.1

*Water molecules are not included.