7LHB
Crystal structure of Bcl-2 in complex with prodrug ABBV-167
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Apoptosis regulator Bcl-2 | polymer | 166 | 19355.6 | 3 | UniProt (P10415) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (Human) | |
2 | A, B, C | Phosphoric acid mono-[5-(5-{4-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-piperazin-1-yl}-2-{3-nitro-4-[(tetrahydro-pyran-4-ylmethyl)-amino]-benzenesulfonylaminocarbonyl}-phenoxy)-pyrrolo[2,3-b]pyridin-7-ylmethyl] ester | non-polymer | 978.4 | 3 | Chemie (XZD) | |||
3 | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 75 (UniProt: P10415)
A, B, C: 76 - 91 (PDB: 7LHB)
A, B, C: 92 - 207 (UniProt: P10415)
PDB | External Database | Details |
---|---|---|
Pro 4 | Ala 4 | engineered mutation |
Lys 26 | Arg 26 | engineered mutation |
A, B, C: 92 - 207 (UniProt: P10415)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 58066.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 2935.3 | |
All* | Total formula weight | 61002.1 |