7LG1
Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cGMP-gated cation channel alpha-1 | polymer | 560 | 64649.4 | 4 | UniProt (P29973) Pfam (PF00520) Pfam (PF00027) Pfam (PF16526) | Homo sapiens (Human) | Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,CNG1,Cyclic nucleotide-gated channel,photoreceptor,Rod photoreceptor cGMP-gated channel subunit alpha |
| 2 | E, G, H, I (A, B, C, D) | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 4 | Chemie (PCG) | |||
| 3 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 144 - 690 (UniProt: P29973)
| PDB | External Database | Details |
|---|---|---|
| Met 131 | - | initiating methionine |
| Asp 132 | - | expression tag |
| Tyr 133 | - | expression tag |
| Lys 134 | - | expression tag |
| Asp 135 | - | expression tag |
| Asp 136 | - | expression tag |
| Asp 137 | - | expression tag |
| Asp 138 | - | expression tag |
| Lys 139 | - | expression tag |
| Gly 140 | - | expression tag |
| Gly 141 | - | expression tag |
| Ser 142 | - | expression tag |
| Ala 143 | - | expression tag |
| Gln 365 | Glu 365 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 258597.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1420.9 | |
| All* | Total formula weight | 260018.7 |
