7LFW

Cryo-EM structure of human cGMP-bound open CNGA1 channel in K+/Ca2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	cGMP-gated cation channel alpha-1	polymer	560	64650.4	4	UniProt (P29973) Pfam (PF00520) Pfam (PF00027) Pfam (PF16526) In PDB	Homo sapiens (Human)	Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,CNG1,Cyclic nucleotide-gated channel,photoreceptor,Rod photoreceptor cGMP-gated channel subunit alpha
2	A, B, C, D	CYCLIC GUANOSINE MONOPHOSPHATE	non-polymer		345.2	4	Chemie (PCG)
3	A	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Sequence modifications

A, B, C, D: 144 - 690 (UniProt: P29973)

PDB	External Database	Details
Met 131	-	initiating methionine
Asp 132	-	expression tag
Tyr 133	-	expression tag
Lys 134	-	expression tag
Asp 135	-	expression tag
Asp 136	-	expression tag
Asp 137	-	expression tag
Asp 138	-	expression tag
Lys 139	-	expression tag
Gly 140	-	expression tag
Gly 141	-	expression tag
Ser 142	-	expression tag
Ala 143	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	258601.7
Non-Polymers*	Number of molecules	6
	Total formula weight	1461.0
All*	Total formula weight	260062.7

*Water molecules are not included.