7LFU

Crystal structure of the SARS CoV-1 Papain-like protease in complex with peptide inhibitor VIR250

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (D)	papain-like protease	polymer	325	36688.5	1	UniProt (P0C6U8) Pfam (PF08715) UniProt (by SIFTS) (P0C6X7)	Severe acute respiratory syndrome coronavirus (SARS-CoV)	pp1a,ORF1a polyprotein
2	B (A)	Papain-like protease peptide inhibitor VIR250	polymer	5	504.6	1	BIRD (PRD_002385)	synthetic construct

Sequence modifications

D: 1 - 317 (UniProt: P0C6U8)

PDB	External Database	Details
Met 0	-	initiating methionine
Leu 318	-	expression tag
Glu 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	37193.1
All*	Total formula weight	37193.1

*Water molecules are not included.