7LFT
Cryo-EM structure of human Apo CNGA1 channel in K+/Ca2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cGMP-gated cation channel alpha-1 | polymer | 560 | 64650.4 | 4 | UniProt (P29973) Pfam (PF00520) Pfam (PF00027) Pfam (PF16526) | Homo sapiens (Human) | Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,CNG1,Cyclic nucleotide-gated channel,photoreceptor,Rod photoreceptor cGMP-gated channel subunit alpha |
| 2 | E, F, FA, GA, P... (A, D, B, C) | CHOLESTEROL | non-polymer | 386.7 | 8 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (18640088) PubChem (1715243) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (1715244) PubChem (23423981) PubChem (45044259) PubChem (638019) PubChem (49853509) PubChem (50990013) PubChem (44654663) PubChem (52934537) PubChem (56621683) PubChem (1549081) PubChem (1553803) PubChem (46937002) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (59274407) PubChem (5283629) PubChem (5284644) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (5315842) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (6419195) PubChem (5997) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (1551269) PubChem (90070115) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (117965027) PubChem (6432564) PubChem (101624109) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (138967089) PubChem (139566851) PubChem (130459183) PubChem (131992107) PubChem (15939944) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (171828367) PubChem (173516975) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 3 | AA, BA, CA, DA, EA... (C, A, D, B) | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 758.1 | 24 | Chemie (CPL) PubChem (16213884) PubChem (46936342) PubChem (5287971) PubChem (6021688) PubChem (6438359) PubChem (122218) PubChem (14389437) PubChem (131706484) | |||
| 4 | M, N, O (A) | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) PubChem (813) | |||
| 5 | NA, OA, PA, QA (A, B, C, D) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 144 - 690 (UniProt: P29973)
| PDB | External Database | Details |
|---|---|---|
| Met 131 | - | initiating methionine |
| Asp 132 | - | expression tag |
| Tyr 133 | - | expression tag |
| Lys 134 | - | expression tag |
| Asp 135 | - | expression tag |
| Asp 136 | - | expression tag |
| Asp 137 | - | expression tag |
| Asp 138 | - | expression tag |
| Lys 139 | - | expression tag |
| Gly 140 | - | expression tag |
| Gly 141 | - | expression tag |
| Ser 142 | - | expression tag |
| Ala 143 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 258601.7 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 21404.0 | |
| All* | Total formula weight | 280005.7 |
