7LF9
Structure of Hyperglycosylated Human IgG1 Fc (Fc329)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | IgG1 Fc (Fc329) | polymer | 233 | 26252.7 | 2 | UniProt (Q6MZV7) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
| 2 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 1 | In PDB GlyTouCan (G64481DJ) | |||
| 3 | D | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1276.2 | 1 | In PDB GlyTouCan (G28663KH) | |||
| 4 | A, B | alpha-L-fucopyranose | non-polymer | 164.2 | 2 | Chemie (FUC) | |||
| 5 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A, B: 216 - 447 (UniProt: Q6MZV7)
| PDB | External Database | Details |
|---|---|---|
| Gly 215 | - | expression tag |
| Asn 329 | Pro 355 | conflict |
| Ser 330 | Ala 356 | conflict |
| Thr 331 | Pro 357 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 52505.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2390.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 549.5 | |
| All* | Total formula weight | 55445.1 |
