7LEK
Crystal structure of the second bromodomain (BD2) of human BRDT bound to ERK5-IN-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Bromodomain testis-specific protein | polymer | 117 | 13704.8 | 4 | UniProt (Q58F21) Pfam (PF00439) In PDB | Homo sapiens (Human) | Cancer/testis antigen 9,CT9,RING3-like protein |
| 2 | A, B, C, D | 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one | non-polymer | 638.8 | 4 | Chemie (VYJ) | |||
| 3 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 266 - 378 (UniProt: Q58F21)
| PDB | External Database | Details |
|---|---|---|
| Gly 262 | - | expression tag |
| Ala 263 | - | expression tag |
| Ala 264 | - | expression tag |
| Ser 265 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 54819.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2652.7 | |
| All* | Total formula weight | 57471.9 |
