7LE0
HIV-1 Protease WT (NL4-3) in Complex with a Darunavir Derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Protease | polymer | 99 | 10831.8 | 2 | UniProt (Q8ULI9) Pfam (PF00077) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | C, D, E, F, G (B, A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | H (A) | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(1,3-benzothiazol-6-yl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate | non-polymer | 589.7 | 1 | Chemie (XUY) | |||
| 4 | I, J (B, A) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 99 (UniProt: Q8ULI9)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21663.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1070.0 | |
| All* | Total formula weight | 22733.7 |
