7LC2
Crystal Structure of KRAS4b-Q61R (GMPPNP-bound) in complex with the RAS-binding domain (RBD) of SIN1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GTPase KRas | polymer | 170 | 19545.5 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | C, D (D, E) | Target of rapamycin complex 2 subunit MAPKAP1 | polymer | 88 | 9824.1 | 2 | UniProt (Q9BPZ7) | Homo sapiens (Human) | TORC2 subunit MAPKAP1,Mitogen-activated protein kinase 2-associated protein 1,Stress-activated map kinase-interacting protein 1,mSIN1 |
| 3 | E, G (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
| 4 | F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | I, J, K (A, B, E) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 169 (UniProt: P01116)
D, E: 275 - 361 (UniProt: Q9BPZ7)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Arg 61 | Gln 61 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 274 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58739.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1093.0 | |
| All* | Total formula weight | 59832.1 |
