7LAY
Crystal structure of the first bromodomain (BD1) of human BRD3 bound to SG3-179
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bromodomain-containing protein 3 | polymer | 123 | 14586.8 | 2 | UniProt (Q15059) Pfam (PF00439) In PDB | Homo sapiens (Human) | RING3-like protein |
| 2 | A, B | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{N}-(1-methylpiperidin-4-yl)benzamide | non-polymer | 604.1 | 2 | Chemie (5W2) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 5 | water | water | 18.0 | 230 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 144 (UniProt: Q15059)
| PDB | External Database | Details |
|---|---|---|
| Ser 22 | - | expression tag |
| Met 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29173.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1426.6 | |
| All* | Total formula weight | 30600.3 |
