7L7E

Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, G, H, O (A, H, I, T)	heavy chain of human monoclonal antibody AZD8895	polymer	225	23942.0	4		Homo sapiens (Human)
2	B, I, J, P (B, J, L, U)	light chain of human monoclonal antibody Fab AZD8895	polymer	216	23574.1	4		Homo sapiens (Human)
3	C, E, K, M (C, E, M, O)	heavy chain of human monoclonal antibody Fab AZD1061	polymer	236	25051.1	4		Homo sapiens (Human)
4	D, F, L, N (D, F, N, P)	light chain of human monoclonal antibody Fab AZD1061	polymer	219	24147.8	4		Homo sapiens (Human)
5	Q, R, S, T (G, K, S, b)	Spike protein S1	polymer	215	24229.2	4	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein,Spike glycoprotein
6	AA, BA, U, V, W... (T, U, A, B, H...)	PHOSPHATE ION	non-polymer		95.0	8	Chemie (PO4)
7	CA, DA, EA, FA (G, K, S, b)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
8	GA, HA, IA, JA, KA... (A, B, C, D, E...)	water	water		18.0	144	Chemie (HOH)

Sequence modifications

G, K, S, b: 330 - 529 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 530	-	expression tag
Leu 531	-	expression tag
Val 532	-	expression tag
Pro 533	-	expression tag
Arg 534	-	expression tag
Gly 535	-	expression tag
Ser 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
His 540	-	expression tag
His 541	-	expression tag
His 542	-	expression tag
His 543	-	expression tag
His 544	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	483776.9
Non-Polymers*	Number of molecules	12
	Total formula weight	1644.6
All*	Total formula weight	485421.5

*Water molecules are not included.