7L7D

Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibody AZD8895

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	heavy chain of human monoclonal antibody Fab AZD8895	polymer	226	24100.3	1		Homo sapiens (Human)
2	B (L)	light chain of human monoclonal antibody Fab AZD8895	polymer	216	23644.2	1		Homo sapiens (Human)
3	C (E)	Spike protein S1	polymer	215	24229.2	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	S glycoprotein,E2,Peplomer protein,Spike glycoprotein
4	D, E, F, G, I... (H, L, E)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
5	H (E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
6	K, L, M (H, L, E)	water	water		18.0	219	Chemie (HOH)

Sequence modifications

E: 330 - 529 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 530	-	expression tag
Leu 531	-	expression tag
Val 532	-	expression tag
Pro 533	-	expression tag
Arg 534	-	expression tag
Gly 535	-	expression tag
Ser 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
His 540	-	expression tag
His 541	-	expression tag
His 542	-	expression tag
His 543	-	expression tag
His 544	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	71973.7
Non-Polymers*	Number of molecules	7
	Total formula weight	773.8
All*	Total formula weight	72747.5

*Water molecules are not included.