7L70

The eukaryotic translation initiation factor 2B from Homo sapiens in its apo form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Translation initiation factor eIF-2B subunit epsilon	polymer	721	80452.6	2	UniProt (Q13144) Pfam (PF02020)	Homo sapiens (Human)	eIF-2B GDP-GTP exchange factor subunit epsilon
2	C, D (C, D)	Translation initiation factor eIF-2B subunit beta	polymer	368	41008.6	2	UniProt (P49770) Pfam (PF01008)	Homo sapiens (Human)	S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta
3	E, F (E, F)	Translation initiation factor eIF-2B subunit delta	polymer	523	57640.2	2	UniProt (Q9UI10) Pfam (PF01008)	Homo sapiens (Human)	eIF-2B GDP-GTP exchange factor subunit delta
4	G, H (G, H)	Translation initiation factor eIF-2B subunit alpha	polymer	322	35723.2	2	UniProt (Q14232) Pfam (PF01008)	Homo sapiens (Human)	eIF-2B GDP-GTP exchange factor subunit alpha
5	I, J (I, J)	Translation initiation factor eIF-2B subunit gamma	polymer	452	50304.2	2	UniProt (Q9NR50) Pfam (PF00483)	Homo sapiens (Human)	eIF-2B GDP-GTP exchange factor subunit gamma

Sequence modifications

A, B: 1 - 721 (UniProt: Q13144)

PDB	External Database	Details
Val 587	Ile 587	conflict

C, D: 2 - 351 (UniProt: P49770)

PDB	External Database	Details
Met -16	-	initiating methionine
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Ser 1	-	expression tag

G, H: 2 - 305 (UniProt: Q14232)

PDB	External Database	Details
Met -16	-	initiating methionine
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	530257.5
All*	Total formula weight	530257.5

*Water molecules are not included.