7L6O
Cryo-EM structure of HIV-1 Env CH848.3.D0949.10.17chim.6R.DS.SOSIP.664
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (a, c, e) | CH848.3.D0949.10.17chim.6R.DS.SOSIP.664 - gp120 | polymer | 466 | 52061.9 | 3 | UniProt (A0A1W6IPB2) Pfam (PF00516) | Human immunodeficiency virus 1 (HIV-1) | Envelope glycoprotein gp120 |
| 2 | B, D, F (b, d, f) | CH848.3.D0949.10.17chim.6R.DS.SOSIP.664 - gp41 | polymer | 146 | 16578.8 | 3 | Pfam (PF00517) UniProt (by SIFTS) (Q2N0S6) | Human immunodeficiency virus 1 | |
| 3 | BA, CA, EA, FA, G... (V, W, Y, Z, A...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 27 | In PDB GlyTouCan (G15407YE) | |||
| 4 | AA, DA, I, IA, N... (U, X, C, i, H...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 5 | K, KA, X (E, k, R) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 6 | AB, BB, CB, DB, EB... (c, d, e, f, a...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) |
Sequence modifications
a, c, e: 34 - 506 (UniProt: A0A1W6IPB2)
| PDB | External Database | Details |
|---|---|---|
| Ala 31 | - | expression tag |
| Glu 32 | - | expression tag |
| Asn 33 | - | expression tag |
| Cys 201 | Val 189 | engineered mutation |
| Cys 433 | Ala 417 | engineered mutation |
| Lys 490 | Glu 474 | engineered mutation |
| Glu 492 | Gln 476 | engineered mutation |
| Val 496 | Ile 480 | engineered mutation |
| Arg 500 | Gly 484 | engineered mutation |
| Cys 501 | Ala 485 | engineered mutation |
| Gly 506 | Glu 491 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 205922.2 | |
| Branched | Number of molecules | 39 |
| Total formula weight | 22388.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3981.7 | |
| All* | Total formula weight | 232292.7 |
