7L5E
Crystal Structure of KPT-330 bound to CRM1 (537-DLTVK-541 to GLCEQ)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTP-binding nuclear protein Ran | polymer | 216 | 24456.1 | 1 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (Human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 2 | B (B) | Ran-specific GTPase-activating protein 1 | polymer | 140 | 16320.7 | 1 | UniProt (P41920) Pfam (PF00638) | Saccharomyces cerevisiae (Baker's yeast) | Chromosome stability protein 20,Perinuclear array-localized protein,Ran-binding protein 1,RANBP1 |
| 3 | C (C) | Exportin-1 | polymer | 1024 | 117442.8 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) | Saccharomyces cerevisiae (Baker's yeast) | Chromosome region maintenance protein 1,Karyopherin-124 |
| 4 | D (A) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | G (C) | selinexor, bound form | non-polymer | 445.3 | 1 | Chemie (V6A) | |||
| 8 | H, I, J (A, B, C) | water | water | 18.0 | 630 | Chemie (HOH) |
Sequence modifications
C: 1 - 1058 (UniProt: P30822)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| - | Val 377 | deletion |
| - | Gln 378 | deletion |
| - | Arg 379 | deletion |
| - | Leu 380 | deletion |
| - | Pro 381 | deletion |
| - | Ala 382 | deletion |
| - | Thr 383 | deletion |
| - | Glu 384 | deletion |
| - | Met 385 | deletion |
| - | Ser 386 | deletion |
| - | Pro 387 | deletion |
| - | Leu 388 | deletion |
| - | Ile 389 | deletion |
| - | Gln 390 | deletion |
| - | Leu 391 | deletion |
| - | Ser 392 | deletion |
| - | Val 393 | deletion |
| - | Gly 394 | deletion |
| - | Ser 395 | deletion |
| - | Gln 396 | deletion |
| - | Ala 397 | deletion |
| - | Ile 398 | deletion |
| - | Ser 399 | deletion |
| - | Thr 400 | deletion |
| - | Gly 401 | deletion |
| - | Ser 402 | deletion |
| - | Gly 403 | deletion |
| - | Ala 404 | deletion |
| - | Leu 405 | deletion |
| - | Asn 406 | deletion |
| - | Pro 407 | deletion |
| - | Glu 408 | deletion |
| - | Tyr 409 | deletion |
| - | Met 410 | deletion |
| - | Lys 411 | deletion |
| - | Arg 412 | deletion |
| - | Phe 413 | deletion |
| Gly 537 | Asp 537 | engineered mutation |
| Cys 539 | Thr 539 | engineered mutation |
| Glu 540 | Val 540 | engineered mutation |
| Gln 541 | Lys 541 | engineered mutation |
| Cys 1022 | Tyr 1022 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 158219.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1083.9 | |
| All* | Total formula weight | 159303.5 |
