7L2M
Cryo-EM structure of DkTx/RTX-bound full-length TRPV1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, C, D, B) | Transient receptor potential cation channel subfamily V member 1 | polymer | 842 | 95328.2 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) | Rattus norvegicus (Rat) | TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like |
| 2 | E, F (E, F) | Tau-theraphotoxin-Hs1a | polymer | 76 | 8684.2 | 2 | UniProt (P0CH43) | Cyriopagopus schmidti (Chinese bird spider) | Tau-TRTX-Hs1a,Double-knot toxin,DkTx |
| 3 | G, I, K, L (A, C, D, B) | resiniferatoxin | non-polymer | 628.7 | 4 | Chemie (6EU) | |||
| 4 | H, J, M (A, C, B) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) |
Sequence modifications
A, C, D, B: 2 - 838 (UniProt: O35433)
E, F: 1 - 75 (UniProt: P0CH43)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 398681.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2583.8 | |
| All* | Total formula weight | 401264.8 |
