7L2M
Cryo-EM structure of DkTx/RTX-bound full-length TRPV1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, C, D, B) | Transient receptor potential cation channel subfamily V member 1 | polymer | 842 | 95328.2 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) | Rattus norvegicus (Rat) | TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like |
| 2 | E, F (E, F) | Tau-theraphotoxin-Hs1a | polymer | 76 | 8684.2 | 2 | UniProt (P0CH43) | Cyriopagopus schmidti (Chinese bird spider) | Tau-TRTX-Hs1a,Double-knot toxin,DkTx |
| 3 | G, I, K, L (A, C, D, B) | resiniferatoxin | non-polymer | 628.7 | 4 | Chemie (6EU) PubChem (2733497) PubChem (44564218) PubChem (176519982) PubChem (104826) PubChem (71718531) PubChem (5148108) PubChem (117893115) PubChem (124525003) PubChem (53776296) PubChem (134688669) PubChem (57090162) PubChem (15814491) PubChem (171342682) PubChem (92845090) PubChem (5311411) PubChem (5702546) PubChem (6324660) PubChem (137635852) PubChem (139248250) | |||
| 4 | H, J, M (A, C, B) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) PubChem (923) |
Sequence modifications
A, C, D, B: 2 - 838 (UniProt: O35433)
E, F: 1 - 75 (UniProt: P0CH43)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 398681.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2583.8 | |
| All* | Total formula weight | 401264.8 |
