7L0S
Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, with AHD
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C | Neurotensin receptor type 1 | polymer | 336 | 37483.0 | 1 | UniProt (P20789) Pfam (PF00001) In PDB | Rattus norvegicus (Rat) | NTR1,High-affinity levocabastine-insensitive neurotensin receptor,NTRH |
2 | D | Neurotensin | polymer | 10 | 1087.3 | 1 | UniProt (P20068) In PDB | Rattus norvegicus (Rat) | |
3 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
4 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 361 | 39983.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
5 | G | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | polymer | 83 | 9593.0 | 1 | UniProt (P63211) Pfam (PF00631) In PDB | Homo sapiens (Human) | Transducin gamma chain |
Sequence modifications
C: 50 - 390 (UniProt: P20789)
D: 8 - 13 (UniProt: P20068)
B: 2 - 340 (UniProt: P62873)
G: 2 - 74 (UniProt: P63211)
PDB | External Database | Details |
---|---|---|
Gly 46 | - | expression tag |
Pro 47 | - | expression tag |
Gly 48 | - | expression tag |
Ser 49 | - | expression tag |
Leu 86 | Ala 86 | engineered mutation |
Asp 103 | His 103 | engineered mutation |
Tyr 105 | His 105 | engineered mutation |
Val 161 | Ala 161 | engineered mutation |
Leu 213 | Arg 213 | engineered mutation |
Leu 234 | Val 234 | engineered mutation |
Ala 253 | Ile 253 | engineered mutation |
- | Glu 273 | deletion |
- | Gln 274 | deletion |
- | Gly 275 | deletion |
- | Arg 276 | deletion |
- | Val 277 | deletion |
- | Cys 278 | deletion |
- | Thr 279 | deletion |
- | Val 280 | deletion |
- | Gly 281 | deletion |
- | Thr 282 | deletion |
- | His 283 | deletion |
- | Asn 284 | deletion |
- | Gly 285 | deletion |
- | Leu 286 | deletion |
- | Glu 287 | deletion |
- | His 288 | deletion |
- | Ser 289 | deletion |
- | Thr 290 | deletion |
Arg 305 | His 305 | engineered mutation |
Val 358 | Phe 358 | engineered mutation |
Ala 362 | Ser 362 | engineered mutation |
Thr 391 | - | expression tag |
Arg 392 | - | expression tag |
Glu 393 | - | expression tag |
Leu 394 | - | expression tag |
Glu 395 | - | expression tag |
Val 396 | - | expression tag |
Leu 397 | - | expression tag |
Phe 398 | - | expression tag |
Gln 399 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 4 | - | expression tag |
Pro 5 | - | expression tag |
Gly 6 | - | expression tag |
Gly 7 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -20 | - | initiating methionine |
Arg -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
Leu -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Leu -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -8 | - | initiating methionine |
Tyr -7 | - | expression tag |
Pro -6 | - | expression tag |
Tyr -5 | - | expression tag |
Asp -4 | - | expression tag |
Val -3 | - | expression tag |
Pro -2 | - | expression tag |
Asp -1 | - | expression tag |
Tyr 0 | - | expression tag |
Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 128562.1 | |
All* | Total formula weight | 128562.1 |