7KZB
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Fab heavy chain of CR3014-C8 antibody | polymer | 231 | 24812.7 | 1 | Homo sapiens | ||
| 2 | B (L) | Fab light chain of CR3014-C8 antibody | polymer | 214 | 23577.0 | 1 | Homo sapiens | ||
| 3 | C (C) | Spike glycoprotein | polymer | 204 | 22975.7 | 1 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | S glycoprotein,E2,Peplomer protein |
| 4 | D (A) | Fab heavy chain of CR3022-B6 antibody | polymer | 230 | 24428.4 | 1 | Homo sapiens | ||
| 5 | E (B) | Fab light chain of CR3022-B6 antibody | polymer | 214 | 23346.9 | 1 | Homo sapiens | ||
| 6 | F (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 7 | G (L) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | H, I (L, C) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
C: 333 - 528 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Gly 529 | - | expression tag |
| Ser 530 | - | expression tag |
| His 531 | - | expression tag |
| His 532 | - | expression tag |
| His 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 119140.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 570.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 119746.7 |
