7KWF

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56N mutant with pyruvate bound in the active site and R,R-bislysine bound at the allosteric site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, F	4-hydroxy-tetrahydrodipicolinate synthase	polymer	310	34161.2	3	UniProt (Q9PPB4) Pfam (PF00701) In PDB	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	HTPA synthase
2	C, D, E	4-hydroxy-tetrahydrodipicolinate synthase	polymer	310	34092.2	3	UniProt (Q9PPB4) Pfam (PF00701) In PDB	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	HTPA synthase
3	B, C, E	(2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid	non-polymer		318.4	3	Chemie (3VN)
4	B, F	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
5	C, D	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
6	E, F	TRIETHYLENE GLYCOL	non-polymer		150.2	2	Chemie (PGE)

Sequence modifications

A, B, F: 1 - 298 (UniProt: Q9PPB4)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Asn 56	His 56	engineered mutation

C, D, E: 1 - 298 (UniProt: Q9PPB4)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Asn 56	His 56	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	204760.2
Non-Polymers*	Number of molecules	9
	Total formula weight	1585.9
All*	Total formula weight	206346.1

*Water molecules are not included.