7KW1
Structure of hSTING in complex with novel carbocyclic pyrimidine CDN-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Stimulator of interferon genes protein | polymer | 243 | 27211.6 | 1 | UniProt (A0A2R3XZB7) Pfam (PF15009) UniProt (by SIFTS) (Q86WV6) In PDB | Homo sapiens (Human) | Transmembrane protein 173 |
| 2 | A | (2R,5R,7R,8R,10R,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-16-hydroxy-14-[(pyrimidin-4-yl)oxy]-2,10-disulfanyldecahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione | non-polymer | 649.5 | 1 | Chemie (X4M) | |||
| 3 | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A: 140 - 379 (UniProt: A0A2R3XZB7)
| PDB | External Database | Details |
|---|---|---|
| Gly 137 | - | expression tag |
| Gly 138 | - | expression tag |
| Ser 139 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27211.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 649.5 | |
| All* | Total formula weight | 27861.1 |
