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7KVK

Human CYP3A4 bound to an inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BCytochrome P450 3A4polymer48755641.62UniProt (P08684)
Pfam (PF00067)
In PDB
Homo sapiens (Human)1,4-cineole 2-exo-monooxygenase,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase (sulfoxide-forming),Albendazole sulfoxidase,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,Nifedipine oxidase,Quinine 3-monooxygenase
2A, BPROTOPORPHYRIN IX CONTAINING FEnon-polymer616.52Chemie (HEM)
3A, Btert-butyl [(2R)-1-{[(2R)-1-oxo-3-phenyl-1-{[3-(pyridin-3-yl)propyl]amino}propan-2-yl]sulfanyl}-3-phenylpropan-2-yl]carbamatenon-polymer533.72Chemie (X7J)
4A, BSULFATE IONnon-polymer96.12Chemie (SO4)
5AGLYCEROLnon-polymer92.12Chemie (GOL)
6A1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
7waterwater18.014Chemie (HOH)
Sequence modifications
A, B: 21 - 503 (UniProt: P08684)
PDBExternal DatabaseDetails
-Leu 3deletion
-Ile 4deletion
-Pro 5deletion
-Asp 6deletion
-Leu 7deletion
-Ala 8deletion
-Met 9deletion
-Glu 10deletion
-Thr 11deletion
-Trp 12deletion
-Leu 13deletion
-Leu 14deletion
-Leu 15deletion
-Ala 16deletion
-Val 17deletion
-Ser 18deletion
-Leu 19deletion
-Val 20deletion
-Leu 21deletion
-Leu 22deletion
Ala 421Lys 421engineered mutation
Ala 424Lys 424engineered mutation
His 504-expression tag
His 505-expression tag
His 506-expression tag
His 507-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight111283.2
Non-Polymers*Number of molecules9
Total formula weight2738.8
All*Total formula weight114022.0
*Water molecules are not included.

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PDB entries from 2024-06-12

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