7KUT
Crystal Structure of Danio rerio Histone Deacetylase 10 H137A Mutant in Complex with N-Acetylputrescine (Tetrahedral Intermediate)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Polyamine deacetylase HDAC10 | polymer | 678 | 75189.8 | 1 | UniProt (F1QCV2) Pfam (PF00850) In PDB | Danio rerio (Zebrafish) | Histone deacetylase 10 |
2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
3 | A | 1-[(4-aminobutyl)amino]ethane-1,1-diol | non-polymer | 148.2 | 1 | Chemie (X51) | |||
4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
5 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
6 | A | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
7 | A | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
8 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
9 | water | water | 18.0 | 329 | Chemie (HOH) |
Sequence modifications
A: 2 - 675 (UniProt: F1QCV2)
PDB | External Database | Details |
---|---|---|
Ser -1 | - | expression tag |
Asn 0 | - | expression tag |
Ala 1 | - | expression tag |
Glu 24 | Ala 24 | conflict |
Ala 94 | Asp 94 | conflict |
Ala 137 | His 137 | engineered mutation |
Phe 154 | Ile 154 | conflict |
Thr 548 | Ser 548 | conflict |
Glu 586 | Gly 586 | conflict |
Arg 593 | Gly 593 | conflict |
Arg 596 | Thr 596 | conflict |
Met 613 | Thr 613 | conflict |
Pro 646 | Leu 646 | conflict |
Trp 676 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 75189.8 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 1341.4 | |
All* | Total formula weight | 76531.1 |