7KUQ
Crystal Structure of Danio rerio Histone Deacetylase 10 Y307F Mutant in Complex with N8-Acetylspermidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Polyamine deacetylase HDAC10 | polymer | 678 | 75240.8 | 1 | UniProt (F1QCV2) Pfam (PF00850) In PDB | Danio rerio (Zebrafish) | Histone deacetylase 10 |
| 2 | A | N-{4-[(3-aminopropyl)amino]butyl}acetamide | non-polymer | 187.3 | 1 | Chemie (Q9C) | |||
| 3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | A | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | A | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 6 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A: 2 - 675 (UniProt: F1QCV2)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
| Glu 24 | Ala 24 | conflict |
| Ala 94 | Asp 94 | conflict |
| Phe 154 | Ile 154 | conflict |
| Phe 307 | Tyr 307 | engineered mutation |
| Thr 548 | Ser 548 | conflict |
| Glu 586 | Gly 586 | conflict |
| Arg 593 | Gly 593 | conflict |
| Arg 596 | Thr 596 | conflict |
| Met 613 | Thr 613 | conflict |
| Pro 646 | Leu 646 | conflict |
| Trp 676 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 75240.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 638.8 | |
| All* | Total formula weight | 75879.6 |
