7KUI
Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. CIC region of a cluster identified by 3-dimensional variability analysis in cryoSPARC.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Integrase | polymer | 278 | 30926.6 | 8 | UniProt (P03354) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) | Rous sarcoma virus (strain Schmidt-Ruppin A) (RSV-PrC) | |
| 2 | I, K (I, K) | DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3') | polymer | 18 | 5520.6 | 2 | Rous sarcoma virus (strain Schmidt-Ruppin A) | ||
| 3 | J, L (J, L) | DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3') | polymer | 16 | 4899.2 | 2 | Rous sarcoma virus (strain Schmidt-Ruppin A) | ||
| 4 | M, O (A, E) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | N, P (A, L) | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide | non-polymer | 461.9 | 2 | Chemie (ZZX) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 278 (UniProt: P03354)
| PDB | External Database | Details |
|---|---|---|
| Lys 166 | Arg 1446 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 268252.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1054.6 | |
| All* | Total formula weight | 269306.9 |
