7KTR

Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein,Transformation/transcription domain-associated protein	polymer	3195	353170.3	1	UniProt (F2Z2U4) Pfam (PF20175) Pfam (PF20206) Pfam (PF02259) Pfam (PF00454) UniProt (by SIFTS) (Q9Y4A5)	Homo sapiens (Human)	TRRAP
2	B (B)	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L	polymer	589	66223.0	1	UniProt (O75529) Pfam (PF00400) Pfam (PF04494)	Homo sapiens (Human)	TAF5L,PCAF-associated factor 65 beta,PAF65-beta
3	C (C)	Isoform 3 of Transcription factor SPT20 homolog	polymer	811	88129.1	1	UniProt (Q8NEM7) Pfam (PF12090)	Homo sapiens (Human)	p38-interacting protein,p38IP, SUPT20H
4	D (D)	STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA,STAGA complex 65 subunit gamma,STAGA complex 65 subunit gamma,DhaA	polymer	704	78079.9	1	UniProt (O94864) Pfam (PF07524)	Homo sapiens	Adenocarcinoma antigen ART1,SPTF-associated factor 65 gamma,STAF65gamma,Suppressor of Ty 7-like, SUPT7L,Adenocarcinoma antigen ART1,SPTF-associated factor 65 gamma,STAF65gamma,Suppressor of Ty 7-like
5	E (E)	Transcription initiation factor TFIID subunit 9B	polymer	251	27654.9	1	UniProt (Q9HBM6) Pfam (PF02291)	Homo sapiens (Human)	Neuronal cell death-related protein 7,DN-7,Transcription initiation factor TFIID subunit 9-like,Transcription-associated factor TAFII31L, TAF9B
6	F (F)	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L	polymer	622	67903.3	1	UniProt (Q9Y6J9) Pfam (PF02969) Pfam (PF07571)	Homo sapiens (Human)	TAF6L,PCAF-associated factor 65-alpha,PAF65-alpha
7	G (G)	Transcription initiation factor TFIID subunit 12	polymer	161	17948.5	1	UniProt (Q16514) Pfam (PF03847)	Homo sapiens (Human)	Transcription initiation factor TFIID 20/15 kDa subunits,TAFII20/TAFII15
8	H (H)	Transcription initiation factor TFIID subunit 10	polymer	218	21731.2	1	UniProt (Q12962) Pfam (PF03540)	Homo sapiens (Human)	STAF28,Transcription initiation factor TFIID 30 kDa subunit,TAFII30
9	I (I)	Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog,Transcription initiation protein SPT3 homolog	polymer	299	33197.0	1	UniProt (O75486) Pfam (PF02269)	Homo sapiens (Human)	SPT3-like protein, SUPT3H,SPT3-like protein
10	J (J)	Transcriptional adapter 1	polymer	335	37432.5	1	UniProt (Q96BN2) Pfam (PF12767)	Homo sapiens (Human)	SPT3-associated factor 42,STAF42,Transcriptional adapter 1-like protein
11	K (N)	Ataxin-7	polymer	892	95597.7	1	UniProt (O15265) Pfam (PF08313)	Homo sapiens (Human)	Spinocerebellar ataxia type 7 protein
12	L (A)	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	1	Chemie (IHP)

Sequence modifications

A: 341 - 360 (PDB: 7KTR)
A: 369 - 1688 (UniProt: F2Z2U4)
A: 1693 - 2290 (PDB: 7KTR)
A: 2300 - 3848 (UniProt: F2Z2U4)
D: 33 - 47 (PDB: 7KTR)
D: 52 - 87 (UniProt: O94864)
D: 96 - 117 (PDB: 7KTR)
D: 119 - 414 (UniProt: O94864)
D: 415 - 749 (PDB: 7KTR)
I: 1 - 156 (UniProt: O75486)
I: 174 - 185 (PDB: 7KTR)
I: 187 - 317 (UniProt: O75486)

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	887067.5
Non-Polymers*	Number of molecules	1
	Total formula weight	660.0
All*	Total formula weight	887727.5

*Water molecules are not included.