7KR7

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56A mutant with pyruvate bound in the active site and L-lysine at the allosteric site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	4-hydroxy-tetrahydrodipicolinate synthase	polymer	310	34118.2	6	UniProt (Q9PPB4) Pfam (PF00701)	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	HTPA synthase
2	CA, G, GA, M, MA... (D, A, E, B, F...)	LYSINE	non-polymer		147.2	6	Chemie (LYS)
3	H, NA, W (A, F, C)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	DA, EA, HA, I, N... (D, E, A, B, C)	TRIETHYLENE GLYCOL	non-polymer		150.2	6	Chemie (PGE)
5	IA, J, K, O, OA... (E, A, B, F, C)	1,2-ETHANEDIOL	non-polymer		62.1	10	Chemie (EDO)
6	AA, BA, FA, JA, KA... (C, D, E, A, F...)	ACETATE ION	non-polymer		59.0	9	Chemie (ACT)
7	LA, RA, SA, T, TA (E, F, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	5	Chemie (PEG)
8	U (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
9	UA, VA, WA, XA, YA... (A, B, C, D, E...)	water	water		18.0	1143	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 298 (UniProt: Q9PPB4)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 56	His 56	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	204709.1
Non-Polymers*	Number of molecules	40
	Total formula weight	3631.9
All*	Total formula weight	208341.0

*Water molecules are not included.