7KPE

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88Q mutant with pyruvate bound in the active site and R,R-bislysine at the allosteric site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	4-hydroxy-tetrahydrodipicolinate synthase	polymer	310	34184.3	6	UniProt (Q9PPB4) Pfam (PF00701)	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	HTPA synthase
2	G, L, N, O, T... (A, B, C, D, E)	MAGNESIUM ION	non-polymer		24.3	7	Chemie (MG)
3	BA, CA, DA, H, R... (F, A, C, D, E)	ACETATE ION	non-polymer		59.0	7	Chemie (ACT)
4	EA, FA, I (F, A)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	GA, J, M, Z (F, A, B, E)	TRIETHYLENE GLYCOL	non-polymer		150.2	4	Chemie (PGE)
6	AA, K, S (F, B, D)	(2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid	non-polymer		318.4	3	Chemie (3VN)
7	P, Q, V (C, D)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
8	HA (F)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
9	IA, JA, KA, LA, MA... (A, B, C, D, E...)	water	water		18.0	1059	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 298 (UniProt: Q9PPB4)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Gln 88	Glu 88	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	205105.6
Non-Polymers*	Number of molecules	28
	Total formula weight	2736.0
All*	Total formula weight	207841.7

*Water molecules are not included.