7KOQ
Alpha-7 nicotinic acetylcholine receptor bound to epibatidine in a desensitized state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Neuronal acetylcholine receptor subunit alpha-7,Soluble cytochrome b562 fusion | polymer | 562 | 63832.3 | 5 | UniProt (P36544) UniProt (P0ABE7) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | Cytochrome b-562 |
| 2 | F, G, H, I, J (F, G, H, I, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 3 | AA, BA, K, L, O... (E, A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 4 | CA, M, Q, U, Y (E, A, B, C, D) | EPIBATIDINE | non-polymer | 208.7 | 5 | Chemie (EPJ) PubChem (1204) PubChem (105084) PubChem (23844116) PubChem (443366) PubChem (44266825) PubChem (44297526) PubChem (44565060) PubChem (44592968) PubChem (854023) PubChem (53299320) PubChem (3073763) PubChem (6544477) PubChem (6604745) PubChem (6951099) PubChem (9859143) PubChem (10081807) PubChem (10176670) PubChem (11031065) PubChem (14976739) PubChem (14976740) PubChem (134963592) PubChem (163809006) | |||
| 5 | DA, N, R, V, Z (E, A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) PubChem (271) |
Sequence modifications
A, B, C, D, E: 1 - 321 (UniProt: P36544)
A, B, C, D, E: 321 - 325 (UniProt: P0ABE7)
A, B, C, D, E: 325 - 479 (UniProt: P36544)
A, B, C, D, E: 321 - 325 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Trp 321 | Met 29 | variant |
| Ile 325 | His 124 | variant |
| Leu 325 | Arg 128 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ala 321 | - | linker |
| Gly 321 | - | linker |
| Ala 321 | - | linker |
| Met 321 | - | linker |
| Trp 480 | - | expression tag |
| Ser 481 | - | expression tag |
| His 482 | - | expression tag |
| Pro 483 | - | expression tag |
| Gln 484 | - | expression tag |
| Phe 485 | - | expression tag |
| Glu 486 | - | expression tag |
| Lys 487 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 319161.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2122.0 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 3455.9 | |
| All* | Total formula weight | 324739.4 |
