7KOO
Alpha-7 nicotinic acetylcholine receptor bound to alpha-bungarotoxin in a resting state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Neuronal acetylcholine receptor subunit alpha-7,Soluble cytochrome b562 fusion | polymer | 562 | 63832.3 | 5 | UniProt (P36544) UniProt (P0ABE7) Pfam (PF02931) Pfam (PF02932) Pfam (PF07361) | Homo sapiens (Human) | Cytochrome b-562 |
| 2 | F, G, H, I, J (F, G, H, I, J) | Alpha-bungarotoxin isoform V31 | polymer | 71 | 7722.0 | 5 | UniProt (P60616) Pfam (PF21947) | Bungarus multicinctus | BGTX V31,Long neurotoxin 1 |
| 3 | K, M, O, Q, S (K, M, O, Q, S) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 5 | In PDB GlyTouCan (G81315DD) | |||
| 4 | L, N, P, R, T (L, N, P, R, T) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 5 | AA, CA, U, W, Y (D, E, A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 6 | BA, DA, V, X, Z (D, E, A, B, C) | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) |
Sequence modifications
A, B, C, D, E: 1 - 322 (UniProt: P36544)
A, B, C, D, E: 322 - 326 (UniProt: P0ABE7)
A, B, C, D, E: 326 - 479 (UniProt: P36544)
A, B, C, D, E: 322 - 326 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Trp 322 | Met 29 | variant |
| Ile 326 | His 124 | variant |
| Leu 326 | Arg 128 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ala 322 | - | linker |
| Gly 322 | - | linker |
| Ala 322 | - | linker |
| Met 322 | - | linker |
| Trp 480 | - | expression tag |
| Ser 481 | - | expression tag |
| His 482 | - | expression tag |
| Pro 483 | - | expression tag |
| Gln 484 | - | expression tag |
| Phe 485 | - | expression tag |
| Glu 486 | - | expression tag |
| Lys 487 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 357771.3 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 5865.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1306.4 | |
| All* | Total formula weight | 364943.2 |
