7KNG

2.10A resolution structure of independent Phosphoglycerate mutase from C. elegans in complex with a macrocyclic peptide inhibitor (Ce-2 Y7F)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	polymer	538	59257.1	2	UniProt (G5EFZ1) Pfam (PF01676) Pfam (PF06415)	Caenorhabditis elegans	iPGM,Cofactor-independent phosphoglycerate mutase homolog
2	C, D (C, D)	DTY-ASP-TYR-PRO-GLY-ASP-PHE-CYS-TYR-LEU-TYR-GLY-THR-CYS	polymer	16	1703.9	2		Caenorhabditis elegans
3	E, F, K, L (A, B)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
4	G, H, M, N (A, B)	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
5	I, J, O, P (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	Q, R, S, T (A, B, C, D)	water	water		18.0	399	Chemie (HOH)

Sequence modifications

A, B: 19 - 539 (UniProt: G5EFZ1)

PDB	External Database	Details
Lys 540	-	expression tag
Leu 541	-	expression tag
Ala 542	-	expression tag
Ala 543	-	expression tag
Ala 544	-	expression tag
Leu 545	-	expression tag
Glu 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag
His 556	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	121921.9
Non-Polymers*	Number of molecules	12
	Total formula weight	495.4
All*	Total formula weight	122417.4

*Water molecules are not included.