7KM0

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59A mutant with pyruvate bound in the active site and R,R-bislysine bound at the allosteric site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	4-hydroxy-tetrahydrodipicolinate synthase	polymer	310	34118.2	6	UniProt (Q9PPB4) Pfam (PF00701)	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	HTPA synthase
2	G (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
3	H, O, Q (A, C, D)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
4	I (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
5	J, K, M, R, S (A, B, D)	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
6	L, P, T (B, D, E)	(2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid	non-polymer		318.4	3	Chemie (3VN)
7	N (B)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
8	U, V, W, X, Y... (A, B, C, D, E...)	water	water		18.0	421	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 298 (UniProt: Q9PPB4)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 59	His 59	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	204709.1
Non-Polymers*	Number of molecules	14
	Total formula weight	1817.5
All*	Total formula weight	206526.6

*Water molecules are not included.