7KLS

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59A mutant with pyruvate bound in the active site and L-lysine bound at the allosteric site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	4-hydroxy-tetrahydrodipicolinate synthase	polymer	310	34118.2	6	UniProt (Q9PPB4) Pfam (PF00701)	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	HTPA synthase
2	G, K, M, R, U... (A, B, C, D, E...)	TRIETHYLENE GLYCOL	non-polymer		150.2	6	Chemie (PGE)
3	H, N, V (A, C, E)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	AA, I, O, P, S... (F, A, C, D, E)	ACETATE ION	non-polymer		59.0	7	Chemie (ACT)
5	BA, J, L, Q, T... (F, A, B, C, D...)	LYSINE	non-polymer		147.2	6	Chemie (LYS)
6	CA, DA, EA, FA, GA... (A, B, C, D, E...)	water	water		18.0	268	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 298 (UniProt: Q9PPB4)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 59	His 59	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	204709.1
Non-Polymers*	Number of molecules	22
	Total formula weight	2270.4
All*	Total formula weight	206979.6

*Water molecules are not included.