7KL2
Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Calcium/calmodulin-dependent protein kinase type II subunit alpha | polymer | 268 | 30548.1 | 1 | UniProt (Q9UQM7) Pfam (PF00069) | Homo sapiens (human) | CaMK-II subunit alpha |
| 2 | B (B) | Glutamate receptor ionotropic, NMDA 2B | polymer | 22 | 2782.2 | 1 | UniProt (Q13224) | Homo sapiens | GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B,N-methyl-D-aspartate receptor subunit 3,hNR3 |
| 3 | C (A) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 7 - 274 (UniProt: Q9UQM7)
B: 1289 - 1310 (UniProt: Q13224)
| PDB | External Database | Details |
|---|---|---|
| Asn 135 | Asp 135 | engineered mutation |
| Lys 223 | Gln 223 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 1303 | Ser 1303 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33330.3 | |
| All* | Total formula weight | 33330.3 |
