7KL1

Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Calcium/calmodulin-dependent protein kinase type II subunit alpha	polymer	268	30548.1	2	UniProt (Q9UQM7) Pfam (PF00069) In PDB	Homo sapiens (human)	CaMK-II subunit alpha
2	C, D	Glutamate receptor ionotropic, NMDA 2B	polymer	22	2782.2	2	UniProt (Q13224) In PDB	Homo sapiens	GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B,N-methyl-D-aspartate receptor subunit 3,hNR3
3	A, B	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
4	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	C, D	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
6		water	water		18.0	118	Chemie (HOH)

Sequence modifications

A, B: 7 - 274 (UniProt: Q9UQM7)

PDB	External Database	Details
Asn 135	Asp 135	engineered mutation
Lys 223	Gln 223	engineered mutation

C, D: 1289 - 1310 (UniProt: Q13224)

PDB	External Database	Details
Asp 1303	Ser 1303	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	66660.5
Non-Polymers*	Number of molecules	7
	Total formula weight	1249.2
All*	Total formula weight	67909.7

*Water molecules are not included.