7KKP
Structure of the catalytic domain of tankyrase 1 in complex with niraparib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Poly [ADP-ribose] polymerase | polymer | 213 | 24356.6 | 2 | UniProt (Q59FX0) Pfam (PF00644) UniProt (by SIFTS) (O95271) In PDB | Homo sapiens (Human) | PARP |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide | non-polymer | 320.4 | 2 | Chemie (3JD) | |||
| 4 | A, B | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 5 | water | water | 18.0 | 540 | Chemie (HOH) |
Sequence modifications
A, B: 1104 - 1314 (UniProt: Q59FX0)
| PDB | External Database | Details |
|---|---|---|
| Gly 1102 | - | expression tag |
| Ser 1103 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48713.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1444.0 | |
| All* | Total formula weight | 50157.2 |
