7KKG

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, N84D mutant with pyruvate bound in the active site and L-lysine bound at the allosteric site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	4-hydroxy-tetrahydrodipicolinate synthase	polymer	310	34186.2	6	UniProt (Q9PPB4) Pfam (PF00701)	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	HTPA synthase
2	AA, AB, BA, BB, CA... (C, F, A, D, B...)	MAGNESIUM ION	non-polymer		24.3	21	Chemie (MG)
3	EA, FA, H (C, A)	SODIUM ION	non-polymer		23.0	3	Chemie (NA)
4	I, PA, S (A, D, B)	TETRAETHYLENE GLYCOL	non-polymer		194.2	3	Chemie (PG4)
5	DB, GA, J, QA, T... (F, C, A, D, B...)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	7	Chemie (PEG)
6	EB, HA, IA, K (F, C, A)	TRIETHYLENE GLYCOL	non-polymer		150.2	4	Chemie (PGE)
7	FB, GB, JA, KA, L... (F, C, A, E)	1,2-ETHANEDIOL	non-polymer		62.1	9	Chemie (EDO)
8	HB, LA, N, RA, U... (F, C, A, D, B...)	LYSINE	non-polymer		147.2	6	Chemie (LYS)
9	V (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
10	IB, JB (F)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
11	KB, LB, MB, NB, OB... (A, B, C, D, E...)	water	water		18.0	2199	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 298 (UniProt: Q9PPB4)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Asp 84	Asn 84	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	205117.5
Non-Polymers*	Number of molecules	56
	Total formula weight	4157.5
All*	Total formula weight	209275.0

*Water molecules are not included.