7KK3
Structure of the catalytic domain of PARP1 in complex with talazoparib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Poly [ADP-ribose] polymerase 1 | polymer | 352 | 39341.0 | 4 | UniProt (P09874) Pfam (PF02877) Pfam (PF00644) In PDB | Homo sapiens (Human) | PARP-1,ADP-ribosyltransferase diphtheria toxin-like 1,ARTD1,DNA ADP-ribosyltransferase PARP1,NAD(+) ADP-ribosyltransferase 1,ADPRT 1,Poly[ADP-ribose] synthase 1,Protein poly-ADP-ribosyltransferase PARP1 |
2 | A, B, C, D | (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one | non-polymer | 380.4 | 4 | Chemie (2YQ) | |||
3 | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 662 - 1011 (UniProt: P09874)
PDB | External Database | Details |
---|---|---|
Gly 660 | - | expression tag |
Ser 661 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 157364.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1521.4 | |
All* | Total formula weight | 158885.4 |