7KJW
Structure of HIV-1 reverse transcriptase initiation complex core with efavirenz
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H | polymer | 562 | 64705.3 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Pr160Gag-Pol |
| 2 | B (B) | reverse transcriptase p51 subunit | polymer | 442 | 51585.3 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus 1 (HIV-1) | |
| 3 | C (C) | HIV-1 viral RNA fragment | polymer | 26 | 8437.1 | 1 | Human immunodeficiency virus 1 | ||
| 4 | D (D) | tRNA lysine 3 fragment with GNRA tetraloop | polymer | 39 | 12595.6 | 1 | Homo sapiens | ||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (A) | (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE | non-polymer | 315.7 | 1 | Chemie (EFZ) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1 - 440 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Val 0 | - | expression tag |
| Cys 258 | Gln 857 | engineered mutation |
| Ser 280 | Cys 879 | conflict |
| Gln 478 | Glu 1077 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Val 0 | - | expression tag |
| Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 137323.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 340.0 | |
| All* | Total formula weight | 137663.3 |
