7KIA
Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 19
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 2 | polymer | 308 | 35327.7 | 2 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (Human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
| 2 | C, F (A, B) | 1-[4-(4-{4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}phenyl)piperidin-1-yl]prop-2-en-1-one | non-polymer | 486.6 | 2 | Chemie (WFD) | |||
| 3 | D, G (A, B) | CITRATE ANION | non-polymer | 189.1 | 2 | Chemie (FLC) | |||
| 4 | E, H (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A, B: 461 - 768 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Phe 564 | Val 564 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70655.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1397.4 | |
| All* | Total formula weight | 72052.7 |
