7KG8
Structure of human PARG complexed with PARG-061
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Poly(ADP-ribose) glycohydrolase | polymer | 531 | 61096.5 | 1 | UniProt (Q86W56) Pfam (PF20811) Pfam (PF05028) | Homo sapiens (Human) | |
| 2 | B (A) | 1,3-dimethyl-8-{[2-(morpholin-4-yl)-2-oxoethyl]sulfanyl}-6-sulfanylidene-1,3,6,7-tetrahydro-2H-purin-2-one | non-polymer | 355.4 | 1 | Chemie (WDM) | |||
| 3 | C, D, E, H (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 4 | F, G (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I (A) | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
| 6 | J (A) | water | water | 18.0 | 434 | Chemie (HOH) |
Sequence modifications
A: 448 - 976 (UniProt: Q86W56)
| PDB | External Database | Details |
|---|---|---|
| Gly 446 | - | expression tag |
| Ser 447 | - | expression tag |
| Ala 616 | Lys 616 | engineered mutation |
| Ala 617 | Gln 617 | engineered mutation |
| Ala 618 | Lys 618 | engineered mutation |
| Ala 688 | Glu 688 | engineered mutation |
| Ala 689 | Lys 689 | engineered mutation |
| Ala 690 | Lys 690 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61096.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 997.1 | |
| All* | Total formula weight | 62093.6 |
