7KG2

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59K mutant with pyruvate bound in the active site and L-histidine bound at the allosteric site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	4-hydroxy-tetrahydrodipicolinate synthase	polymer	310	34176.3	6	UniProt (A0A2U0QMK8) Pfam (PF00701) UniProt (by SIFTS) (Q9PPB4)	Campylobacter jejuni	HTPA synthase
2	AA, AB, BA, BB, CB... (B, D, A, F, C...)	1,2-ETHANEDIOL	non-polymer		62.1	38	Chemie (EDO)
3	CA, DA, DB, EB, FB... (B, D, F, A, C...)	MAGNESIUM ION	non-polymer		24.3	14	Chemie (MG)
4	EA, FA, GA, GB, HB... (B, D, F, C, A...)	ACETATE ION	non-polymer		59.0	15	Chemie (ACT)
5	AC, BC, CC, HA, IA... (E, B, D, C, A)	TRIETHYLENE GLYCOL	non-polymer		150.2	8	Chemie (PGE)
6	FC, JA, OB, OC, TA... (E, B, D, F, C...)	HISTIDINE	non-polymer		156.2	6	Chemie (HIS)
7	KB (D)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
8	DC, EC, LB, MB, NB (E, D)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	5	Chemie (PEG)
9	PC, QC, RC, SC, TC... (A, B, C, D, E...)	water	water		18.0	761	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 298 (UniProt: A0A2U0QMK8)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Lys 59	His 59	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	205057.8
Non-Polymers*	Number of molecules	87
	Total formula weight	6447.7
All*	Total formula weight	211505.5

*Water molecules are not included.