7KG1
Structure of human PARG complexed with PARG-002
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Poly(ADP-ribose) glycohydrolase | polymer | 531 | 61020.4 | 1 | UniProt (Q86W56) Pfam (PF20811) Pfam (PF05028) | Homo sapiens (Human) | |
| 2 | B, C, D, F (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 3 | E (A) | 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]amino}-3,7-dihydro-1H-purine-2,6-dione | non-polymer | 308.3 | 1 | Chemie (WDD) | |||
| 4 | G, H (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | I (A) | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
| 6 | J, K, L, M, N (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 7 | O (A) | water | water | 18.0 | 303 | Chemie (HOH) |
Sequence modifications
A: 448 - 976 (UniProt: Q86W56)
| PDB | External Database | Details |
|---|---|---|
| Gly 446 | - | expression tag |
| Ser 447 | - | expression tag |
| Ala 616 | Lys 616 | engineered mutation |
| Ala 617 | Gln 617 | engineered mutation |
| Ala 618 | Lys 618 | engineered mutation |
| Ala 688 | Glu 688 | engineered mutation |
| Ala 689 | Lys 689 | engineered mutation |
| Ala 690 | Lys 690 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61020.4 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1422.4 | |
| All* | Total formula weight | 62442.7 |
