7KFB

Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-442

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I (A, B, C)	Virion spike glycoprotein 1	polymer	313	34978.6	3	UniProt (A0A1C4HDV6) Pfam (PF01611) UniProt (by SIFTS) (Q05320)	Ebola virus
2	B, F, J (G, H, I)	Antibody Fab EBOV-442 heavy chain	polymer	240	25294.3	3		Homo sapiens (human)
3	C, G, K (J, K, L)	Antibody Fab EBOV-442 light chain	polymer	215	23715.3	3		Homo sapiens (human)
4	D, H, L (D, E, F)	Virion spike glycoprotein 2	polymer	203	22158.6	3	UniProt (A0A0E3XK95) Pfam (PF22307) UniProt (by SIFTS) (Q05320)	Ebola virus
5	M, O, P, R, S... (M, O, P, R, S...)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	6	In PDB GlyTouCan (G22768VO)
6	N, Q, T (N, Q, T)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
7	AA, V, W, X, Y... (C, A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)

Sequence modifications

A, B, C: 32 - 309 (UniProt: A0A1C4HDV6)

PDB	External Database	Details
Met -3	-	expression tag
Asp -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag
Lys 1	-	expression tag
Arg 2	-	expression tag
Gly 3	-	expression tag
Leu 4	-	expression tag
Cys 5	-	expression tag
Cys 6	-	expression tag
Val 7	-	expression tag
Leu 8	-	expression tag
Leu 9	-	expression tag
Leu 10	-	expression tag
Cys 11	-	expression tag
Gly 12	-	expression tag
Ala 13	-	expression tag
Val 14	-	expression tag
Phe 15	-	expression tag
Val 16	-	expression tag
Ser 17	-	expression tag
Pro 18	-	expression tag
Ser 19	-	expression tag
Gln 20	-	expression tag
Glu 21	-	expression tag
Ile 22	-	expression tag
His 23	-	expression tag
Ala 24	-	expression tag
Arg 25	-	expression tag
Phe 26	-	expression tag
Arg 27	-	expression tag
Arg 28	-	expression tag
Gly 29	-	expression tag
Ala 30	-	expression tag
Arg 31	-	expression tag

D, E, F: 461 - 629 (UniProt: A0A0E3XK95)

PDB	External Database	Details
Asp 630	-	expression tag
Asp 631	-	expression tag
Asp 632	-	expression tag
Lys 633	-	expression tag
Ala 634	-	expression tag
Gly 635	-	expression tag
Trp 636	-	expression tag
Ser 637	-	expression tag
His 638	-	expression tag
Pro 639	-	expression tag
Gln 640	-	expression tag
Phe 641	-	expression tag
Glu 642	-	expression tag
Lys 643	-	expression tag
Gly 644	-	expression tag
Gly 645	-	expression tag
Gly 646	-	expression tag
Ser 647	-	expression tag
Gly 648	-	expression tag
Gly 649	-	expression tag
Gly 650	-	expression tag
Ser 651	-	expression tag
Gly 652	-	expression tag
Gly 653	-	expression tag
Gly 654	-	expression tag
Ser 655	-	expression tag
Trp 656	-	expression tag
Ser 657	-	expression tag
His 658	-	expression tag
Pro 659	-	expression tag
Gln 660	-	expression tag
Phe 661	-	expression tag
Glu 662	-	expression tag
Lys 663	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	318440.4
Branched	Number of molecules	9
	Total formula weight	6738.1
Non-Polymers*	Number of molecules	6
	Total formula weight	1327.2
All*	Total formula weight	326505.8

*Water molecules are not included.