7KF0

Crystal structure of bH1 Fab variant (CDR H3 loop design 13_0346) in complex with VEGF

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H, A	anti-VEGF-A Fab bH1 heavy chain	polymer	236	25376.4	2		Homo sapiens
2	L, B	anti-VEGF-A Fab bH1 light chain	polymer	218	23956.6	2		Homo sapiens
3	V, C	Isoform L-VEGF206 of Vascular endothelial growth factor A	polymer	116	13548.4	2	UniProt (P15692-14) Pfam (PF00341) UniProt (by SIFTS) (P15692) In PDB	Homo sapiens (Human)	VEGF-A,Vascular permeability factor,VPF
4	L, B	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6		water	water		18.0	486	Chemie (HOH)

Sequence modifications

V, C: 1 - 110 (UniProt: P15692-14)

PDB	External Database	Details
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
His 114	-	expression tag
His 115	-	expression tag
His 116	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	125762.8
Non-Polymers*	Number of molecules	3
	Total formula weight	159.6
All*	Total formula weight	125922.4

*Water molecules are not included.