7KEV

PCSK9 in complex with a cyclic peptide LDLR disruptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proprotein convertase subtilisin/kexin type 9 Propeptide	polymer	124	14019.7	1	UniProt (Q8NBP7) Pfam (PF05922) In PDB	Homo sapiens (Human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
2	B	Proprotein convertase subtilisin/kexin type 9	polymer	546	58272.6	1	UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) In PDB	Homo sapiens (Human)	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
3	C	cyclic peptide LDLR disruptor	polymer	14	1724.0	1		synthetic construct
4	B	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5		water	water		18.0	17	Chemie (HOH)

Sequence modifications

B: 153 - 692 (UniProt: Q8NBP7)

PDB	External Database	Details
Ile 474	Val 474	variant
Glu 670	Gly 670	variant
His 693	-	expression tag
His 694	-	expression tag
His 695	-	expression tag
His 696	-	expression tag
His 697	-	expression tag
His 698	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	74016.3
Non-Polymers*	Number of molecules	1
	Total formula weight	40.1
All*	Total formula weight	74056.4

*Water molecules are not included.