7KE0
HIV-1 Integrase catalytic core domain complexed with allosteric inhibitor STP03-0404
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrase | polymer | 166 | 18443.7 | 1 | UniProt (F2WR52) Pfam (PF00665) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 (HIV-1) | |
| 2 | B (A) | (2S)-tert-butoxy{4-(4-chlorophenyl)-2,3,6-trimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid | non-polymer | 495.0 | 1 | Chemie (WBV) | |||
| 3 | C (A) | water | water | 18.0 | 29 | Chemie (HOH) |
Sequence modifications
A: 50 - 212 (UniProt: F2WR52)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| His 49 | - | expression tag |
| His 185 | Phe 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18443.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 495.0 | |
| All* | Total formula weight | 18938.7 |
