7KCF
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AGI-24512
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | S-adenosylmethionine synthase isoform type-2 | polymer | 396 | 43807.7 | 1 | UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) In PDB | Homo sapiens (Human) | AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II |
| 2 | A | 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one | non-polymer | 400.5 | 1 | Chemie (J4A) | |||
| 3 | A | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 544 | Chemie (HOH) |
Sequence modifications
A: 1 - 395 (UniProt: P31153)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43807.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1077.2 | |
| All* | Total formula weight | 44884.9 |
